An attempt has been made to develop buccal mucoadhesive bilayered tablet comprising of drug containing bioadhesive core layer and drug free backing layer to release the drug for sustained period of time. Buccal tablets of Atenolol were prepared by direct compression method. Mucoadhesive polymers Carbopol (CP934P), Hydroxylpropylmethyl cellulose (HPMC K4M), Polyvinylpyrolidone (PVP K32) in combination with backing layer of ethyl cellulose were used. The formulations were then evaluated with respect to physical characteristics, surface pH, swelling index, mucoadhesive strength, disintegration time, In vitro drug release and In vitro permeation. The tablets were evaluated for In vitro drug release in phosphate buffer pH 6.8 for 8 hr using USP Type 2 dissolution test apparatus. The physical characteristics, surface pH, swelling index, bioadhesive strength, disintegration time and In vitro drug release were shown to be dependent on characteristics and composition of bioadhesive material used. Formulation F2 showed maximum release of the drug (93.02 ± 0.4%) with non fickian release mechanism and permeated 54.21 ± 2.9% of the drug through sheep buccal membrane. The present study proves that mucoadhesive bilayered tablets of Atenolol with controlled drug release properties can be successfully prepared by direct compression method using HPMC K4M and Polyvinyl pyrollidone K32 as mucoadhesive polymers and ethyl cellulose as backing layer.
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